New Insulin Pill Shows Positive Results in Rodent Models

A new insulin pill has shown positive results in a Harvard study with rodents, researchers say. While the concept of the insulin pill is not new, there are currently no products available on the commercial market. The biggest challenge with an insulin pill is that the digestive system tends to break down and destroy insulin itself.

The Harvard researchers tried a new approach with their version of the insulin pill by dispersing the insulin in liquid made from choline and geranic acid. When administered to rats, their blood sugar levels fell by about half, the effects lasting four hours. The researchers theorize the suspension of the insulin in the choline/geranic acid liquid prevents the digestive system from destroying the medicine, allowing it to be absorbed into the blood stream.

The researchers concluded, “Evidence from cell and animal studies supports a promising prospect of development of the formulation into a clinical product." You can read the full findings online via Proceedings of the National Academy of Sciences.