The Guide for the Care and Use of Laboratory Animals (or the Guide) is published by the National Research Council, written and revised by a committee of experts appointed by the National Academies’ Institute for Laboratory Animal Resources with input from scientists and the public. A comprehensive and respected information resource for decades, the Guide incorporates research about all commonly used animal species including extensive references. It treats the following subjects: institutional policies and procedures; animal environment, husbandry and management; veterinary care and research facilities’ physical plant. The 2010 revision of the Guide is now being prepared for final publication.

The Public Health Service (PHS) Policy mandates that institutions use the Guide (NRC 1996) as a basis for developing and implementing a program for activities involving animals. It is the primary resource used by AAALAC's Council on Accreditation to evaluate animal care and use programs, and is widely recognized throughout the international scientific community.