The Animal research Behind the Top 25 most Prescribed Drugs

Compiled using publicly available information from the FDA, the Top 25 Most Prescribed Drugs table is easy to read and clearly demonstrates the indispensable role animal models play in the drug development process. The table can be customized to sort by species so readers can learn which pharmaceuticals were developed thanks to the assistance of rodents, nonhuman primates (NHP), dogs, or rabbits.

Chances are someone you know is taking one of the most commonly prescribed FDA-approved medications on this list. These include medications for high cholesterol, high blood pressure, asthma, and diabetes; all of which could not have been developed without the assistance of animal research. Yet, a common tactic by opponents of lifesaving and life-improving biomedical research with animals is to attempt to discredit its effectiveness.  With this information, the evidence is irrefutable. Please share it with the public, your colleagues, and cross post on social media to help increase awareness of the necessity of animal models in drug development.

RankDrug Drug UsageSpecies
1SynthroidEnlarged thyroid; hypothyroidismRats, Dogs, Mice
2CrestorHigh cholesterolRats, Beagle dogs, Mice, Cats, Cynomolgus monkeys, Rabbits
3NexiumHeartburn; Acid RefluxRats, Beagle dogs, Rabbits, Mice
4Ventolin HFABronchospasmRats, Beagle dogs, New Zealand white rabbits
5Advair DiskusAsthma; COPD Flare-upsRats, Dogs, Mice, Rabbits, Guinea pigs, Monkeys, Hamsters
6DiovanHigh Blood PressureRats, Mice, Rabbits, Marmosets
7Lantus SolostarDiabetes mellitusRats, Beagle Dogs, Rabbits, Guinea Pigs
8CymbaltaFibromyalgia; Major Depressive & General Anxiety DisordersMice, Rats, Rabbits, Dogs
9VyvanseADHD; Severe binge eating (adults)Rats, Guinea Pigs, Beagle Dogs
10LyricaFibromyalgia; EpilepsyMice, Rats, Monkeys, Rabbits
11Spiriva HandihalerCOPD (including Bronchitis & Emphysema)Mice, Rats, Rabbits, Dogs
12LantusTypes 1 & 2 DiabetesMice, Dogs, Guinea Pigs, Rats
13CelebrexArthritis; Ankylosing SpondylitisRats, Mice, Beagle Dogs, Monkeys
14AbilifySchizophrenia & Bipolar DisorderRats, Dogs, Monkeys, Rabbits
15JanuviaType 2 DiabetesRats, Rabbits, Dogs, Monkeys
16NamendaModerate to Severe DementiaRats, Mice, Beagle Dogs
17ViagraErectile DysfunctionRats, Dogs, Mice, Rabbits
18CialisErectile DysfunctionMice, Beagle Dogs, Wistar Rats
19ZetiaHigh cholesterolRats, Dogs, Mice
20NasonexSeasonal/Year Round AllergiesRats, Rabbits, Dogs
21SuboxoneNarcotic AddictionMice, Rats, Rabbits, Baboons, Dogs
22SymbicortAsthmaMice, Rats, Dogs
23BystolicHypertensionMice, Rats, Dogs
24Flovent HFAPrevent Asthma AttacksRats, Rabbits, Dogs
25OxycontinLong lasting, Moderate to Severe PainRats, Rabbits

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View Drugs Tested By Species

RATS

RankDrug (Brand Name)Drug Usage
1SynthroidEnlarged thyroid; hypothyroidism
2CrestorHigh cholesterol
3NexiumHeartburn; Acid Reflux
4Ventolin HFABronchospasm
5Advair DiskusAsthma; COPD Flare-ups
6DiovanHigh Blood Pressure
7Lantus SolostarDiabetes mellitus
8CymbaltaFibromyalgia; Major Depressive & General Anxiety Disorders
9VyvanseADHD; Severe binge eating (adults)
10LyricaFibromyalgia; Epilepsy
11Spiriva HandihalerCOPD (including Bronchitis & Emphysema)
12LantusTypes 1 & 2 Diabetes
13CelebrexArthritis; Ankylosing Spondylitis
14AbilifySchizophrenia & Bipolar Disorder
15JanuviaType 2 Diabetes
16NamendaModerate to Severe Dementia
17ViagraErectile Dysfunction
18CialisErectile Dysfunction
19ZetiaHigh cholesterol
20NasonexSeasonal/Year Round Allergies
21SuboxoneNarcotic Addiction
22SymbicortAsthma
23BystolicHypertension
24Flovent HFAPrevent Asthma Attacks
25OxycontinLong lasting, Moderate to Severe Pain

MICE

RankDrug (Brand Name)Drug Usage
1SynthroidEnlarged thyroid; hypothyroidism
2CrestorHigh cholesterol
3NexiumHeartburn; Acid Reflux
5Advair DiskusAsthma; COPD Flare-ups
6DiovanHigh Blood Pressure
8CymbaltaFibromyalgia; Major Depressive & General Anxiety Disorders
10LyricaFibromyalgia; Epilepsy
11Spiriva HandihalerCOPD (including Bronchitis & Emphysema)
12LantusTypes 1 & 2 Diabetes
13CelebrexArthritis; Ankylosing Spondylitis
16NamendaModerate to Severe Dementia
17ViagraErectile Dysfunction
18CialisErectile Dysfunction
19ZetiaHigh cholesterol
21SuboxoneNarcotic Addiction
22SymbicortAsthma
23BystolicHypertension

NONHUMAN PRIMATES

RankDrug (Brand Name)Drug Usage
2CrestorHigh cholesterol
5Advair DiskusAsthma; COPD Flare-ups
10LyricaFibromyalgia; Epilepsy
13CelebrexArthritis; Ankylosing Spondylitis
14AbilifySchizophrenia & Bipolar Disorder
15JanuviaType 2 Diabetes
21SuboxoneNarcotic Addiction

DOGS

RankDrug (Brand Name)Drug Usage
1SynthroidEnlarged thyroid; hypothyroidism
2CrestorHigh cholesterol
3NexiumHeartburn; Acid Reflux
4Ventolin HFABronchospasm
5Advair DiskusAsthma; COPD Flare-ups
7Lantus SolostarDiabetes mellitus
8CymbaltaFibromyalgia; Major Depressive & General Anxiety Disorders
9VyvanseADHD; Severe binge eating (adults)
11Spiriva HandihalerCOPD (including Bronchitis & Emphysema)
12LantusTypes 1 & 2 Diabetes
13CelebrexArthritis; Ankylosing Spondylitis
14AbilifySchizophrenia & Bipolar Disorder
15JanuviaType 2 Diabetes
16NamendaModerate to Severe Dementia
17ViagraErectile Dysfunction
18CialisErectile Dysfunction
19ZetiaHigh cholesterol
20NasonexSeasonal/Year Round Allergies
21SuboxoneNarcotic Addiction
22SymbicortAsthma
23BystolicHypertension
24Flovent HFAPrevent Asthma Attacks

RABBITS

RankDrug (Brand Name)Drug Usage
2CrestorHigh cholesterol
3NexiumHeartburn; Acid Reflux
4Ventolin HFABronchospasm
5Advair DiskusAsthma; COPD Flare-ups
6DiovanHigh Blood Pressure
7Lantus SolostarDiabetes mellitus
8CymbaltaFibromyalgia; Major Depressive & General Anxiety Disorders
10LyricaFibromyalgia; Epilepsy
11Spiriva HandihalerCOPD (including Bronchitis & Emphysema)
14AbilifySchizophrenia & Bipolar Disorder
15JanuviaType 2 Diabetes
17ViagraErectile Dysfunction
20NasonexSeasonal/Year Round Allergies
21SuboxoneNarcotic Addiction
24Flovent HFAPrevent Asthma Attacks
25OxycontinLong lasting, Moderate to Severe Pain

References

Food and Drug Administration New Drug Application Database Accessed May, 2015.

Brooks M. Top 100 Most Prescribed, Top-Selling Drugs. Medscape. Aug 1, 2014. Accessed May, 2015.