Research leading to almost every Nobel Prize in Medicine awarded since 1901 was dependent on data from animal models. This fact dramatically demonstrates the important contribution animal models in biomedical research make to both international and American medical progress. In fact, since 1979, every Nobel Prize in Medicine awarded was dependent on data from animal models with the exception of the 1983 Prize awarded to Dr. Barbara McClintock for her work in plant genetics.
Year
Nobel Laureate
Animal Model
Contribution to Modern Medicine
2011
Bruce A. Beutler
Mice
Discoveries concerning the activation of innate immunity
Jules A. Hoffmann
Flies
Ralph M. Steinman
For his discovery of the dendritic cell and its role in adaptive immunity
2010
Robert G. Edwards
Rabbits
The development of in vitro fertilization
2009
Carol W. Greider
Protzoan, mouse, frog
Discovery of how chromosomes are protected by telomeres and the enzyme telomerase
Elizabeth H. Blackburn
Protzoan, mouse
Jack W. Szostak
Protzoan
2008
Harald zur Hausen
Hamster, mouse, cow
Discovery of human papilloma viruses causing cervical cancer
Françoise Barré-Sinoussi
Monkey, chimpanzee, mouse
Discovery of human immunodeficiency virus
Luc Montagnier
2007
Mario R. Capecchi
Mouse
Discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells
Sir Martin J. Evans
Mouse, Chick
Oliver Smithies
2006
Andrew Z. Fire
Nematode roundworm
Discovery of RNA interference - gene silencing by double-stranded RNA
Craig C. Mello
2005
Barry J. Marshall
Piglet
Discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease
2004
Richard Axel
Mouse, Drosophila (fruit flies)
Discoveries of odorant receptors and the organization of the olfactory system
Linda B. Buck
Discoveries of odorant receptors and the organization of the olfactory system"
2003
Paul C. Lauterbur
Clam, mouse, dog, rat, chimpanzee, pig, rabbit, frog
Discoveries concerning magnetic resonance imaging (MRI)
Sir Peter Mansfield
2002
H. Robert Horvitz
Nematode
Genetic regulation of organ development and programmed cell death
Sydney Brenner
John E. Sulston
2001
Leland H. Hartwell
Sea urchin, frog
Discoveries of key regulators of the cell cycle
Tim Hunt
Sea urchin, frog, Rabbit, Xenopus, Clam
Sir Paul M. Nurse
2000
Arvid Carlsson
Sea slug, mouse
Discoveries in signal transduction in the nervous system
Paul Greengard
Eric R. Kandel
1999
Günter Blobel
Mouse, rat, dog
Discovery that proteins have intrinsic signals that govern their transport and localization in the cell
1998
Robert F. Furchgott
Rabbit
Regulation of blood pressure with nitric oxide (NO)
Louis J. Ignarro
Ferid Murad
1997
Stanley B. Prusiner
Mouse, hamster
Discovery of prions, a new biological principle of infection
1996
Peter C. Doherty
Recognition of virus-infected cells by the immune system
Rolf M. Zinkernagel
1995
Edward B. Lewis
Fruit fly
Genetic control of early embryonic development
Christiane Nüsslein-Volhard
Eric F. Wieschaus
1994
Alfred G. Gilman
Rat, cow, rabbit, turkey
Discovery of G-proteins and the role of these proteins in signal transduction in cells
Martin Rodbell
Rat, guinea pig, turkey
1993
Richard J. Roberts
Rats
Discoveries of split genes
Phillip A. Sharp
1992
Edmond H. Fischer
Discoveries concerning reversible protein phosphorylation as a biological regulatory mechanism
Edwin G. Krebs
Rabbit, Rat
1991
Erwin Neher
Frog
Chemical communication between cells
Bert Sakmann
1990
Joseph E. Murray
Dog
Organ transplantation techniques
E. Donnall Thomas
1989
Harold E. Varmus
Chicken
Discovery of the cellular origin of retroviral oncogenes
J. Michael Bishop
1988
Sir James W. Black
Guinea pig, cat, dog, rat
Discoveries of important principles for drug treatment
Gertrude B. Elion
Mice, dog, rabbit, monkey
George H. Hitchings
Mice, rat, dog
1987
Susumu Tonegawa
Mouse embryo
Discovery of genetic principle for generation of antibody diversity
1986
Stanley Cohen
Mouse, chick, snake
Nerve growth factor and epidermal growth factor
Rita Levi-Montalcini
1985
Michael S. Brown
Discoveries concerning the regulation of cholesterol metabolism
Joseph L. Goldstein
1984
Niels K. Jerne
Techniques of monoclonal antibody formation
Georges J.F. Köhler
César Milstein
1982
Sune K. Bergström
Rat, rabbit, guinea pig
Discovery of prostaglandins
Bengt I. Samuelsson
John R. Vane
1981
Roger W. Sperry
Cat, monkey
Discoveries concerning the functional specialization of the cerebral hemispheres
David H. Hubel
Discoveries concerning information processing in the visual system
Torsten N. Wiesel
1980
Baruj Benacerraf
Mouse, guinea pig
Identification of histocompatibility antigens and mechanism of action
Jean Dausset
George D. Snell
1979
Allan M. Cormack
Pig
Development of computer assisted tomography (CAT scan)
Godfrey N. Hounsfield
1977
Roger Guillemin
Sheep, pig
Discoveries concerning the peptide hormone production of the brain
Andrew V. Schally
Rosalyn Yalow
Development of radioimmunoassays of peptide hormones
1976
Baruch S. Blumberg
Chimpanzee
New mechanisms for the origin and dissemination of infectious diseases
D. Carleton Gajdusek
1975
David Baltimore
Monkey, horse, chicken, mouse
Interaction between tumor viruses and gentic material
Renato Dulbecco
Howard Martin Temin
1974
Albert Claude
Chicken, guinea pig, rat
Structural and functional organization of cells
Christian de Duve
George E. Palade
1973
Karl von Frisch
Bee, bird, fish
Organization of social and behavior patterns in animals
Konrad Lorenz
Nikolaas Tinbergen
1972
Gerald M. Edelman
Guinea pig, rabbit
Chemical structure of antibodies
Rodney R. Porter
1971
Earl W. Sutherland, Jr.
Mammalian liver
Mechanism of the actions of hormones
1970
Sir Bernard Katz
Cat, rat
Mechanism of storage and release of nerve transmitters
Ulf von Euler
Julius Axelrod
1968
Robert W. Holley
Rat
Interpretation of the genetic code and its function in protein synthesis
Har Gobind Khorana
Marshall W. Nirenberg
Primary physiological and chemical processes of vision
1967
Ragnar Granit
Chicken, rabbit, fish, crab
Haldan Keffer Hartline
George Wald
1966
Peyton Rous
Rat, rabbit, hen
Discovery of tumour-inducing viruses
Charles Brenton Huggins
Discoveries concerning hormonal treatment of prostatic cancer
1964
Konrad Bloch
Regulation of cholesterol and fatty acid metabolism
Feodor Lynen
1963
Sir John Carew Eccles
Cat, frog, squid, crab
Ionic mechanisms involved in excitation and inhibition in the peripheral and central portions of the nerve cell membrane
Alan Lloyd Hodgkin
Andrew Fielding Huxley
1961
Georg von Békésy
Guinea pig
Physical mechanism of stimulation within the cochlea
1960
Sir Frank Macfarlane Burnet
Discovery of acquired immunological tolerance
Peter Brian Medawar
1957
Daniel Bovet
Dog, rabbit
Production of synthetic compounds and their action on the vascular system and skeletal muscles
1955
Axel Hugo Theodor Theorell
Horse
Nature and mode of action of oxidation enzymes
1954
John Franklin Enders
Monkey, mouse
Culture of poliovirus that led to development of vaccine
Thomas Huckle Weller
Frederick Chapman Robbins
1953
Hans Adolf Krebs
Pigeon
Discovery of the citric acid cycle
Fritz Albert Lipmann
Discovery of co-enzyme A and its importance in intermediary metabolism
1952
Selman Abraham Waksman
Discovery of streptomycin, the first effective antibiotic against tuberculosis
1951
Max Theiler
Development of yellow fever vaccine
1950
Edward Calvin Kendall
Cow
Antiarthritic role of adrenal hormones
Tadeus Reichstein
Philip Showalter Hench
1949
Walter Rudolf Hess
Cat
Functional organization of the brain as a coordinator of internal organs
Antonio Caetano de Abreu Freire Egas Moniz
Discovery of the therapeutic value of leucotomy in certain psychoses
1947
Carl Ferdinand Cori
Frog, toad, dog
Catalytic conversion glycogen
Gerty Theresa Cori, née Radnitz
Bernardo Alberto Houssay
Role of pituitary in sugar metabolism
1945
Sir Alexander Fleming
Discovery of penicillin and its curative effect in various infectious diseases
Ernst Boris Chain
Sir Howard Walter Florey
1944
Joseph Erlanger
Specific functions of nerve cells
Herbert Spencer Gasser
1943
Henrik Carl Peter Dam
Rat, dog, chick, mouse
Discovery of function of Vitamin K
Edward Adelbert Doisy
1939
Gerhard Domagk
Mouse, rabbit
Antibacterial effects of prontosil
1938
Corneille Jean François Heymans
Role of the sinus and aortic mechanisms in regulation of respirtation
1936
Sir Henry Hallett Dale
Cat, frog, bird, reptile
Chemical transmission of nerve impulses
Otto Loewi
1935
Hans Spemann
Newt, frog
Organizer effect in embryonic development
1934
George Hoyt Whipple
Liver therapy for anemia
George Richards Minot
William Parry Murphy
1932
Sir Charles Scott Sherrington
Dog, cat
Function of neurons
Edgar Douglas Adrian
1929
Christiaan Eijkman
Discovery of antineuritic and growth stimulating vitamins
Sir Frederick Gowland Hopkins
1928
Charles Jules Henri Nicolle
Monkey, guinea pig, rat, mouse
Pathogenesis of typhus
1924
Willem Einthoven
Mechanism of the electrocardiogram
1923
Frederick Grant Banting
Dog, rabbit, fish
Discovery of insulin and mechanism of diabetes
John James Richard Macleod
1922
Archibald Vivian Hill
Discovery relating to the production of heat in the muscle
1920
Schack August Steenberg Krogh
Discovery of capillary motor regulating mechanism
1919
Jules Bordet
Guinea pig, horse, rabbit
Mechanisms of immunity
1913
Charles Robert Richet
Mechanisms of anaphylaxis
1912
Alexis Carrel
Surgical advances in the suture and grafting of blood vessels
1910
Albrecht Kossel
Bird
Knowledge of cell chemistry through work on proteins, including nuclear substances
1908
Ilya Ilyich Mechnikov
Bird, fish, guinea pig
Immune reactions and functions of phagocytes
Paul Ehrlich
1907
Charles Louis Alphonse Laveran
Role of protozoa as cause of disease
1906
Camillo Golgi
Dog, horse
Characterization of the central nervous system
Santiago Ramón y Cajal
1905
Robert Koch
Cow, sheep
Studies of pathogenesis of tuberculosis
1904
Ivan Petrovich Pavlov
Animal responses to various stimuli
1902
Ronald Ross
Understanding of malaria life cycle
1901
Emil Adolf von Behring
Guinea Pig
Development of diphtheria antiserum
Thanks to animal research, many diseases that once killed millions of people every year are either treatable or have been eradicated altogether. Immunizations against polio, diphtheria, mumps, rubella, and hepatitis save countless lives, and the survival rates from many major diseases are at an all time high thanks to our increased understanding of the etiology of disease, the discovery of new drugs, and the development of new medical devices and surgical procedures.
Animal research has played a vital role in virtually every major medical advance of the last century – for both human and animal health. From antibiotics to blood transfusions, dialysis to organ-transplantation, vaccinations to chemotherapy, bypass surgery to joint replacement, practically every present day protocol for the prevention, treatment, cure, and control of disease, pain, and suffering has at its core knowledge attained through research that included work with animals.
In 1901, Emil von Behring was awarded the first Nobel Prize in Physiology or Medicine for his work on serum therapy, particularly for its use in the treatment of diphtheria. The Nobel Prize in Medicine has subsequently highlighted a number of important discoveries including penicillin, genetic engineering and blood-typing. - courtesy http://nobelprize.org
National Association for Biomedical Research818 Connecticut Avenue, NW, Suite 900, Washington, D.C. 20006202.857.0540 | (FAX) 202.659.1902Copyright 2010-2011 National Association for Biomedical Research. All Rights Reserved.Privacy Policy | Sitemap