The U.S. Environmental Protection Agency (EPA) enforces "Good Laboratory Practice" (GLP) regulations that apply to all studies related to approvals of new pesticides or industrial chemicals "to ensure the quality and integrity of test data submitted to the Agency under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and the Toxic Substances Control Act (TSCA)." The GLPs address all areas of laboratory operations, including provisions specifying standard operating procedures for the housing, feeding, handling and care of animals. The EPA compliance monitoring program inspects facilities, audits data and prepares detailed inspection reports. Noncompliance with GLPs can result in the federal agency's refusal to consider a study in support of an application; disqualification of the testing facility; or, in extreme cases, recommendation for criminal prosecution.

EPA Good Laboratory Practice Standards (full text)

Subpart A - General Provisions
Sec. 160.1 Scope
Sec. 160.15 Inspection of a testing facility.

Subpart C - Facilities
Sec. 160.43 Test system care facilities.
Sec. 160.45 Test system supply facilities.

Subpart E - Testing Facilities Operation
Sec. 160.90 Animal and other test system care.

FEDERAL LEGISLATION

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Animal Cruelty
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